Role of Cytokines on Synaptic Plasticity in the Dentate Gyrus - Derval Cumiskey
Pro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer¿s disease. Tumour necrosis factor-¿ (TNF-¿) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF-¿ and IL-18 mediated inhibition of LTP. Initial experiments..