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Discussion Framework for Clinical Trial Data Sharing - Committee On Strategies For Responsible Sharing Of Clinical Trial Data - Bog - National

Discussion Framework for Clinical Trial Data Sharing - Committee On Strategies For Responsible Sharing Of Clinical Trial Data - Bog - National

Sharing data generated through the conduct of clinical trials offers the promise of placing evidence about the safety and efficacy of therapies and clinical interventions on a firmer basis and enhancing the benefits of clinical trials. Ultimately, such data sharing - if carried out appropriately - could lead to improved clinical care and greater public trust in clinical research and health care. Discussion Framework for Clinical Trial Data Sharing: Guiding Principles, Elements, and Activities is part of a study of how data from clinical trials might best be shared. This document is designed as a framework for discussion and public comment. This framework is being released to stimulate reactions and comments from stakeholders and the public. The framework summarizes the committee's initial thoughts on guiding principles that underpin responsible sharing of clinical trial data, defines key elements of clinical trial data and data sharing, and describes a selected set of clinical trial data sharing activities. Table of ContentsFront MatterDiscussion Framework for Clinical Trial Data SharingReferencesAppendix A: Statement of TaskAppendix B: Committee BiographiesAppendix C: Figure 1: Data Flow from Participant to Analyzed Data and Reporting

DKK 266.00
3

Examining Core Elements of International Research Collaboration - National Academy Of Engineering - Bog - National Academies Press - Plusbog.dk

Examining Core Elements of International Research Collaboration - National Academy Of Engineering - Bog - National Academies Press - Plusbog.dk

The globalization of science, engineering, and medical research is proceeding rapidly. The globalization of research has important implications for the U.S. research enterprise, for the U.S. government agencies, academic institutions, and companies that support and perform research, and for the world at large. As science and technology capabilities grow around the world, U.S.-based organizations are finding that international collaborations and partnerships provide unique opportunities to enhance research and training. At the same time, significant obstacles exist to smooth collaboration across national borders. Enhancing international collaboration requires recognition of differences in culture, legitimate national security needs, and critical needs in education and training. In response to these trends, the Government-University-Industry Research Roundtable (GUIRR) launched a Working Group on International Research Collaborations (I-Group) in 2008, following its meeting on New Partnerships on a Global Platform that June. As part of I-Group's continuing effort, a workshop on Examining Core Elements of International Research Collaboration was held July 26-27, 2010 in Washington, DC. One primary goal of the workshop is to better understand the risks involved in international research collaboration for organizations and individual participants, and the mechanisms that can be used to manage those risks. Issues to be addressed in the workshop include the following: (1) Cultural Differences and Nuances; (2) Legal Issues and Agreements; (3) Differences in Ethical Standards; (4) Research Integrity and the Responsible Conduct of Research; (5) Intellectual Property; (6) Risk Management; (7) Export Controls; and (8) Strategies for Developing Meaningful International Collaborations. The goal for the workshop and the summary, Examining Core Elements of International Research Collaboration, is to serve as an information resource for participants and others interested in international research collaborations. It will also aid I-Group in setting its future goals and priorities. Table of ContentsFront Matter1 Introduction2 Creating an Environment for Productive International Collaboration3 Cultural Differences and Nuances4 Ethics5 Research Integrity and the Responsible Conduct of Research6 Risk Management7 Intellectual Property8 Export Controls9 Legal Issues and Agreements10 Summary DiscussionAppendix A: Workshop AgendaAppendix B: Workshop ParticipantsAppendix C: Bio Sketches of Planning Committee Members, Workshop Agenda Speakers and Staff

DKK 253.00
3

Analysis of Global Change Assessments - National Research Council - Bog - National Academies Press - Plusbog.dk

Analysis of Global Change Assessments - National Research Council - Bog - National Academies Press - Plusbog.dk

Global change assessments inform decision makers about the scientific underpinnings of a range of environmental issues, such as climate change, stratospheric ozone depletion, and loss of biodiversity. Dozens of assessments have been conducted to date by various U.S. and international groups, many of them influencing public policies, technology development, and research directions. This report analyzes strengths and weaknesses of eight past assessments to inform future efforts. Common elements of effective assessments include strong leadership, extensive engagement with interested and affected parties, a transparent science-policy interface, and well defined communication strategies. The report identifies 11 essential elements of effective assessments and recommends that future assessments include decision support tools that make use of information at the regional and local level where decisions are made.

DKK 370.00
1

A Review of the DOE Plan for U.S. Fusion Community Participation in the ITER Program - Plasma Science Committee - Bog - National Academies Press -

A Review of the DOE Plan for U.S. Fusion Community Participation in the ITER Program - Plasma Science Committee - Bog - National Academies Press -

ITER presents the United States and its international partners with the opportunity to explore new and exciting frontiers of plasma science while bringing the promise of fusion energy closer to reality. This book assesses the US Department of Energy (DOE) plan for US fusion community participation in ITER, and evaluates the plan's elements.

DKK 290.00
1

Review of the Space Communications Program of NASA's Space Operations Mission Directorate - Committee To Review Nasa's Space Communications Program -

Review of the Space Communications Program of NASA's Space Operations Mission Directorate - Committee To Review Nasa's Space Communications Program -

The Space Communications Office (SCO) at NASA has two primary roles. The first is to manage two of the communications networks that enable spaceflight operations and research, and the second is to integrate agency-wide telecommunications issues. This report presents a review of each of the program elements within the SCO and the space network.

DKK 208.00
3

Incorporating Occupational Information in Electronic Health Records - Board On Health Sciences Policy - Bog - National Academies Press - Plusbog.dk

Incorporating Occupational Information in Electronic Health Records - Board On Health Sciences Policy - Bog - National Academies Press - Plusbog.dk

Each year in the United States, more than 4,000 occupational fatalities and more than 3 million occupational injuries occur along with more than 160,000 cases of occupational illnesses. Incorporating patients' occupational information into electronic health records (EHRs) could lead to more informed clinical diagnosis and treatment plans as well as more effective policies, interventions, and prevention strategies to improve the overall health of the working population. At the request of the National Institute for Occupational Safety and Health, the IOM appointed a committee to examine the rationale and feasibility of incorporating occupational information in patients' EHRs. The IOM concluded that three data elements - occupation, industry, and work-relatedness - were ready for immediate focus, and made recommendations on moving forward efforts to incorporate these elements into EHRs. Table of ContentsFront MatterIncorporating Occupational Information in Electronic Health RecordsAppendix A: Workshop AgendaAppendix B: Workshop ParticipantsAppendix C: Committee Biographies

DKK 240.00
1

2013-2014 Assessment of the Army Research Laboratory - National Research Council - Bog - National Academies Press - Plusbog.dk

2013-2014 Assessment of the Army Research Laboratory - National Research Council - Bog - National Academies Press - Plusbog.dk

The National Research Council's Army Research Laboratory Technical Assessment Board provides biennial assessments of the scientific and technical quality of the research, development, and analysis programs at the Army Research Laboratory, focusing on ballistics sciences, human sciences, information sciences, materials sciences, and mechanical sciences. This interim report summarizes the findings of the Board for the first year of this biennial assessment. During the first year the Board examined the following elements: within ballistic sciences, terminal ballistics; within human sciences, translational neuroscience and soldier simulation and training technology; within information sciences, autonomous systems; and within materials sciences, energy materials and devices, photonic materials and devices, and biomaterials. The review of autonomous systems included examination of the mechanical sciences competency area for autonomous systems. A second, final report will subsume the findings of this interim report and add the findings from the second year of the review, during which the Board will examine additional elements.

DKK 240.00
1

Global Change and Extreme Hydrology - Water Science And Technology Board - Bog - National Academies Press - Plusbog.dk

Global Change and Extreme Hydrology - Water Science And Technology Board - Bog - National Academies Press - Plusbog.dk

Climate theory dictates that core elements of the climate system, including precipitation, evapotranspiration, and reservoirs of atmospheric and soil moisture, should change as the climate warms, both in their means and extremes. A major challenge that faces the climate and hydrologic science communities is understanding the nature of these ongoing changes in climate and hydrology and the apparent anomalies that exist in reconciling their extreme manifestations. The National Research Council (NRC) Committee on Hydrologic Science (COHS) held a workshop on January 5-6, 2010, that examined how climate warming translates into hydrologic extremes like floods and droughts. The workshop brought together three groups of experts. The first two groups consisted of atmospheric scientists and hydrologists focused on the scientific underpinnings and empirical evidence linking climate variability to hydrologic extremes. The third group consisted of water managers and decision-makers charged with the design and operation of water systems that in the future must be made resilient in light of a changing climate and an environment of hydrologic extremes. Global Change and Extreme Hydrology summarizes the proceedings of this workshop. This report presents an overview of the current state of the science in terms of climate change and extreme hydrologic events. It examines the "conventional wisdom" that climate change will "accelerate" the hydrologic cycle, fuel more evaporation, and generate more precipitation, based on an increased capacity of a warmer atmosphere to hold more water vapor. The report also includes descriptions of the changes in frequency and severity of extremes, the ability (or inability) to model these changes, and the problem of communicating the best science to water resources practitioners in useful forums. Table of ContentsFront MatterSummaryIntroductionFindingsReferencesAppendixesAppendix A: Statement of TaskAppendix B: AgendaAppendix C: Speaker AbstractsAppendix D: Summary of PresentationsAppendix E: Workshop Participants

DKK 201.00
3

Autonomy Research for Civil Aviation - Committee On Autonomy Research For Civil Aviation - Bog - National Academies Press - Plusbog.dk

Autonomy Research for Civil Aviation - Committee On Autonomy Research For Civil Aviation - Bog - National Academies Press - Plusbog.dk

The development and application of increasingly autonomous (IA) systems for civil aviation is proceeding at an accelerating pace, driven by the expectation that such systems will return significant benefits in terms of safety, reliability, efficiency, affordability, and/or previously unattainable mission capabilities. IA systems range from current automatic systems such as autopilots and remotely piloted unmanned aircraft to more highly sophisticated systems that are needed to enable a fully autonomous aircraft that does not require a pilot or human air traffic controllers. These systems, characterized by their ability to perform more complex mission-related tasks with substantially less human intervention for more extended periods of time, sometimes at remote distances, are being envisioned for aircraft and for air traffic management and other ground-based elements of the national airspace system. Civil aviation is on the threshold of potentially revolutionary improvements in aviation capabilities and operations associated with IA systems. These systems, however, face substantial barriers to integration into the national airspace system without degrading its safety or efficiency. Autonomy Research for Civil Aviation identifies key barriers and suggests major elements of a national research agenda to address those barriers and help realize the benefits that IA systems can make to crewed aircraft, unmanned aircraft systems, and ground-based elements of the national airspace system. This report develops a set of integrated and comprehensive technical goals and objectives of importance to the civil aeronautics community and the nation. Autonomy Research for Civil Aviation will be of interest to U.S. research organizations, industry, and academia who have a role in meeting these goals.

DKK 292.00
1

Monitoring Climate Change Impacts - National Research Council - Bog - National Academies Press - Plusbog.dk

Monitoring Climate Change Impacts - National Research Council - Bog - National Academies Press - Plusbog.dk

The stresses associated with climate change are expected to be felt keenly as human population grows to a projected 9 billion by the middle of this century, increasing the demand for resources and supporting infrastructure. Therefore, information to assess vulnerabilities to climate change is needed to support policies and investments designed to increase resilience in human and Earth systems. There are currently many observing systems that capture elements of how climate is changing, for example, direct measurements of atmospheric and ocean temperature. Although those measurements are essential for understanding the scale and nature of climate change, they do not necessarily provide information about the impacts of climate change on humans that are especially relevant for political and economic planning and decision making. Monitoring Climate Change Impacts tackles the challenge of developing an illustrative suite of indicators, measurements (and the locations around the globe where the measurements can be applied), and metrics that are important for understanding global climate change and providing insight into environmental sustainability. Eight panels provided input on: cryosphere, land-surface and terrestrial ecosystems, hydrology and water resources, atmosphere, human health and other dimensions, oceans (both physical and biological/chemical), and natural disasters. The book also provides an illustrative set of metrics that are likely to be affected by climate change over the next 20-25 years and, when taken together, can potentially give advance warning of climate-related changes to the human and environment systems. Table of ContentsFront MatterSummary1 Introduction2 Domains of Human Vulnerability and Global-Scale Processes3 Climate Change Metrics at the Intersection of the Human and Earth Systems4 Final ThoughtsReferencesAppendix A: Statement of TaskAppendix B: Working Document: Topical Panel BreakoutsAppendix C: Committee and Staff Biosketches

DKK 266.00
3