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Practical Guide to ChIP-seq Data Analysis

Bio-Inspired Fault-Tolerant Algorithms for Network-on-Chip

Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery

Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery

The microfluidic lab-on-a-chip allows scientists to conduct chemical and biochemical analysis in a miniaturized format so small that properties and effects are successfully enhanced and processes seamlessly integrated. This microscale advantage translates into greater sensitivity more accurate results and better information. Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery focuses on all aspects of the microfluidic lab-on-a-chip technologies and offers an overview of the available technology its limitations and its breakthroughs over the years. It emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods microfluidic operations chemical separations sample preparation and injection methods detection technology and various chemical and biological analyses. Other topics of interest include the use of polymeric chips fluid flow valve and control single-cell analysis DNA and RNA amplification techniques DNA hybridization immunoassays and enzymatic assays. Originally conceived as a single chapter published in Ewing's Analytical Instrumentation this book is a gateway to the vast literature and conference proceedings on the topic. Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery expands upon its roots to present a comprehensive treatment of microfluidic lab-on-a-chip methods and applications for novices and advanced researchers alike.

GBP 44.99
1

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery

Lab-on-a-chip technology permits us to make many important discoveries that can only be observed at the microscale or the nanoscale. Using this technology biological and biochemical analyses translate into greater sensitivity more accurate results and more valuable findings. Authored by one of the fields pioneering researchers Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery focuses on all key aspects of microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science its limitations breakthroughs made over the years and currently emerging advances. The book emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods microfluidic operations chemical separations sample preparation and injection methods detection technology and various chemical and biological analyses. Other topics of interest include the use of polymeric chips fluid flow valve and control single-cell analysis DNA and RNA amplification techniques DNA hybridization immunoassays and enzymatic assays. The book includes more than 300 figures that depict novel chip functions and breakthroughs and 16 tables summarize materials and refer readers to additional resources. An appendix compiles extensive analytical applications from emerging and established research groups. Beginners in the field will find the book useful for navigating the vast literature related to the technology while experienced researchers will rely on the compiled information for easy comparison and references for further study. Derived from the highly popular Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery (2006) this volume is also readily adaptable for classroom use. Problem sets in each chapter help students test their assimilation of the material and clarify challenging conce

GBP 175.00
1

Digital Microfluidic Biochips Design Automation and Optimization

Digital Microfluidic Biochips Design Automation and Optimization

Microfluidics-based biochips combine electronics with biochemistry providing access to new application areas in a wide variety of fields. Continued technological innovations are essential to assuring the future role of these chips in functional diversification in biotech pharmaceuticals and other industries. Revolutionary guidance on design optimization and testing of low-cost disposable biochips Microfluidic Biochips: Design Automation and Optimization comprehensively covers the appropriate design tools and in-system automation methods that will help users adapt to new technology and progress in chip design and manufacturing. Based on results from several Duke University research projects on design automation for biochips this book uses real-life bioassays as examples to lay out an automated design flow for creating microfluidic biochips. It also develops solutions to the unique problems associated with that process. Highlights the design of the protein crystallization chip to illustrate the benefits of automated design flowIn addition to covering automated design the authors provide a detailed methodology for the testing use and optimization of robust cost-efficient manufacturable digital microfluidic systems used in protein crystallization and other areas. The invaluable tools and practices presented here will help readers to: Address optimization problems related to layout synthesis droplet routing and testing for digital microfluidic biochips Make routing-aware architectural-level design choices and defect-tolerant physical design decisions simultaneously Achieve the optimization goal which includes minimizing time-to-response chip area and test complexity Effectively deal with practical issues such as defects fabrication cost physical constraints and application-driven design The authors present specialized pin-constrained design techniques for making biochips with a focus on cost and disposability. They also discuss chip testing to ensure dependability which is key to optimizing safety-critical applications such as point-of-care medical diagnostics on-chip DNA analysis automated drug discovery air-quality monitoring and food-safety testing. This book is an optimal reference for academic and industrial researchers in the areas of digital microfluidic biochips and electronic design automation. | Digital Microfluidic Biochips Design Automation and Optimization

GBP 69.99
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Semiconductor Packaging Materials Interaction and Reliability

Reconfigurable Computing Systems Engineering Virtualization of Computing Architecture

CMOS Analog Integrated Circuits High-Speed and Power-Efficient Design Second Edition

Handbook of Silicon Semiconductor Metrology

Metal Cutting Mechanics

Influence of Temperature on Microelectronics and System Reliability A Physics of Failure Approach

Influence of Temperature on Microelectronics and System Reliability A Physics of Failure Approach

This book raises the level of understanding of thermal design criteria. It provides the design team with sufficient knowledge to help them evaluate device architecture trade-offs and the effects of operating temperatures. The author provides readers a sound scientific basis for system operation at realistic steady state temperatures without reliability penalties. Higher temperature performance than is commonly recommended is shown to be cost effective in production for life cycle costs. The microelectronic package considered in the book is assumed to consist of a semiconductor device with first-level interconnects that may be wirebonds flip-chip or tape automated bonds; die attach; substrate; substrate attach; case; lid; lid seal; and lead seal. The temperature effects on electrical parameters of both bipolar and MOSFET devices are discussed and models quantifying the temperature effects on package elements are identified. Temperature-related models have been used to derive derating criteria for determining the maximum and minimum allowable temperature stresses for a given microelectronic package architecture. The first chapter outlines problems with some of the current modeling strategies. The next two chapters present microelectronic device failure mechanisms in terms of their dependence on steady state temperature temperature cycle temperature gradient and rate of change of temperature at the chip and package level. Physics-of-failure based models used to characterize these failure mechanisms are identified and the variabilities in temperature dependence of each of the failure mechanisms are characterized. Chapters 4 and 5 describe the effects of temperature on the performance characteristics of MOS and bipolar devices. Chapter 6 discusses using high-temperature stress screens including burn-in for high-reliability applications. The burn-in conditions used by some manufacturers are examined and a physics-of-failure approach is described. The | Influence of Temperature on Microelectronics and System Reliability A Physics of Failure Approach

GBP 59.99
1

CMOS Analog Integrated Circuits High-Speed and Power-Efficient Design

CMOS Analog Integrated Circuits High-Speed and Power-Efficient Design

High-speed power-efficient analog integrated circuits can be used as standalone devices or to interface modern digital signal processors and micro-controllers in various applications including multimedia communication instrumentation and control systems. New architectures and low device geometry of complementary metaloxidesemiconductor (CMOS) technologies have accelerated the movement toward system on a chip design which merges analog circuits with digital and radio-frequency components. CMOS: Analog Integrated Circuits: High-Speed and Power-Efficient Design describes the important trends in designing these analog circuits and provides a complete in-depth examination of design techniques and circuit architectures emphasizing practical aspects of integrated circuit implementation. Focusing on designing and verifying analog integrated circuits the author reviews design techniques for more complex components such as amplifiers comparators and multipliers. The book details all aspects from specification to the final chip of the development and implementation process of filters analog-to-digital converters (ADCs) digital-to-analog converters (DACs) phase-locked loops (PLLs) and delay-locked loops (DLLs). It also describes different equivalent transistor models design and fabrication considerations for high-density integrated circuits in deep-submicrometer process circuit structures for the design of current mirrors and voltage references topologies of suitable amplifiers continuous-time and switched-capacitor circuits modulator architectures and approaches to improve linearity of Nyquist converters. The text addresses the architectures and performance limitation issues affecting circuit operation and provides conceptual and practical solutions to problems that can arise in the design process. This reference provides balanced coverage of theoretical and practical issues that will allow the reader to design CMOS analog integrated circuits with improved electrical performance. The chapters contain easy-to-follow mathematical derivations of all equations and formulas graphical plots and open-ended design problems to help determine most suitable architecture for a given set of performance specifications. This comprehensive and illustrative text for the design and analysis of CMOS analog integrated circuits serves as a valuable resource for analog circuit designers and graduate students in electrical engineering. | CMOS Analog Integrated Circuits High-Speed and Power-Efficient Design

GBP 77.99
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Analog Electronics for Radiation Detection

Mobile Point-of-Care Monitors and Diagnostic Device Design

CMOS Analog and Mixed-Signal Circuit Design Practices and Innovations

Electronic Design Automation for Integrated Circuits Handbook Second Edition - Two Volume Set

Mixed-Signal Circuits

Mixed-Signal Circuits

Mixed-Signal Circuits offers a thoroughly modern treatment of integrated circuit design in the context of mixed-signal applications. Featuring chapters authored by leading experts from industry and academia this book:Discusses signal integrity and large-scale simulation verification and testingDemonstrates advanced design techniques that enable digital circuits and sensitive analog circuits to coexist without any compromiseDescribes the process technology needed to address the performance challenges associated with developing complex mixed-signal circuitsDeals with modeling topics such as reliability variability and crosstalk that define pre-silicon design methodology and trends and are the focus of companies involved in wireless applicationsDevelops methods to move analog into the digital domain quickly minimizing and eliminating common trade-offs between performance power consumption simulation time verification size and costDetails approaches for very low-power performances high-speed interfaces phase-locked loops (PLLs) voltage-controlled oscillators (VCOs) analog-to-digital converters (ADCs) and biomedical filtersDelineates the respective parts of a full system-on-chip (SoC) from the digital parts to the baseband blocks radio frequency (RF) circuitries electrostatic-discharge (ESD) structures and built-in self-test (BIST) architecturesMixed-Signal Circuits explores exciting opportunities in wireless communications and beyond. The book is a must for anyone involved in mixed-signal circuit design for future technologies.

GBP 59.99
1

Electronic Design Automation for IC System Design Verification and Testing

Electronic Design Automation for IC System Design Verification and Testing

The first of two volumes in the Electronic Design Automation for Integrated Circuits Handbook Second Edition Electronic Design Automation for IC System Design Verification and Testing thoroughly examines system-level design microarchitectural design logic verification and testing. Chapters contributed by leading experts authoritatively discuss processor modeling and design tools using performance metrics to select microprocessor cores for integrated circuit (IC) designs design and verification languages digital simulation hardware acceleration and emulation and much more. New to This Edition: Major updates appearing in the initial phases of the design flow where the level of abstraction keeps rising to support more functionality with lower non-recurring engineering (NRE) costs Significant revisions reflected in the final phases of the design flow where the complexity due to smaller and smaller geometries is compounded by the slow progress of shorter wavelength lithography New coverage of cutting-edge applications and approaches realized in the decade since publication of the previous edition—these are illustrated by new chapters on high-level synthesis system-on-chip (SoC) block-based design and back-annotating system-level models Offering improved depth and modernity Electronic Design Automation for IC System Design Verification and Testing provides a valuable state-of-the-art reference for electronic design automation (EDA) students researchers and professionals.

GBP 74.99
1

Testing for Small-Delay Defects in Nanoscale CMOS Integrated Circuits

Testing for Small-Delay Defects in Nanoscale CMOS Integrated Circuits

Advances in design methods and process technologies have resulted in a continuous increase in the complexity of integrated circuits (ICs). However the increased complexity and nanometer-size features of modern ICs make them susceptible to manufacturing defects as well as performance and quality issues. Testing for Small-Delay Defects in Nanoscale CMOS Integrated Circuits covers common problems in areas such as process variations power supply noise crosstalk resistive opens/bridges and design-for-manufacturing (DfM)-related rule violations. The book also addresses testing for small-delay defects (SDDs) which can cause immediate timing failures on both critical and non-critical paths in the circuit. Overviews semiconductor industry test challenges and the need for SDD testing including basic concepts and introductory material Describes algorithmic solutions incorporated in commercial tools from Mentor Graphics Reviews SDD testing based on alternative methods that explores new metrics top-off ATPG and circuit topology-based solutions Highlights the advantages and disadvantages of a diverse set of metrics and identifies scope for improvement Written from the triple viewpoint of university researchers EDA tool developers and chip designers and tool users this book is the first of its kind to address all aspects of SDD testing from such a diverse perspective. The book is designed as a one-stop reference for current industrial practices research challenges in the domain of SDD testing and recent developments in SDD solutions.

GBP 74.99
1

Fluorescence Sensors and Biosensors

Fluorescence Sensors and Biosensors

Fluorescence-based sensing is a significant technique used in prominent fields such as fluorescence-activated cell sorting DNA sequencing high-throughput screening and clinical diagnostics. Fluorescence Sensors and Biosensors emphasizes the most recent developments and emerging technologies with the broadest impacts. The text begins with the development of aptamers (oligoribonucleotides) and biorecognition techniques based on periplasmic binding proteins. The following chapters review the molecular beacon approach for DNA recognition describe resonance energy transfer (FRET) in sensing and present the use of carbonic anhydrase recognition platform for metal ion determination and imaging. The book explores the advantages of fluorophores fluorescent labels sensor and assay construction metal-enhanced fluorescence phosphorescent labels and lab-on-a-chip applications. It also describes new anion-selective fluorescent probes used as analytes in clinical determinations. The final chapters highlight the application of fluorescence sensing technology to several practical problems such as the development of planar waveguide biosensors for clinical diagnostics and the adaptation of fluorescence-based sensing approaches for biochemical production by fermentation. The book also discusses the measurement of analytes such as free zinc ions at ultratrace levels in biological specimens. Written by internationally renowned authors in their fields Fluorescence Sensors and Biosensors provides an up-to-date account of fluorescence-based sensors focused on practical applications in biotechnology analytical chemistry and biomedicine.

GBP 59.99
1

Applications of Field-Programmable Gate Arrays in Scientific Research

Applications of Field-Programmable Gate Arrays in Scientific Research

Focusing on resource awareness in field-programmable gate array (FPGA) design Applications of Field-Programmable Gate Arrays in Scientific Research covers the principle of FPGAs and their functionality. It explores a host of applications ranging from small one-chip laboratory systems to large-scale applications in big science. The book first describes various FPGA resources including logic elements RAM multipliers microprocessors and content-addressable memory. It then presents principles and methods for controlling resources such as process sequencing location constraints and intellectual property cores. The remainder of the book illustrates examples of applications in high-energy physics space and radiobiology. Throughout the text the authors remind designers to pay attention to resources at the planning design and implementation stages of an FPGA application in order to reduce the use of limited silicon resources and thereby reduce system cost. Supplying practical know-how on an array of FPGA application examples this book provides an accessible overview of the use of FPGAs in data acquisition signal processing and transmission. It shows how FPGAs are employed in laboratory applications and how they are flexible low-cost alternatives to commercial data acquisition systems. Web Resource A supporting website at http://scipp. ucsc. edu/~hartmut/FPGA offers more details on FPGA programming and usage. The site contains design elements of the case studies from the book including VHDL code detailed schematics of selected projects photographs and screen shots.

GBP 69.99
1

Medical Infrared Imaging Principles and Practices

Medical Infrared Imaging Principles and Practices

The evolution of technological advances in infrared sensor technology image processing smart algorithms knowledge-based databases and their overall system integration has resulted in new methods of research and use in medical infrared imaging. The development of infrared cameras with focal plane arrays no longer requiring cooling added a new dimension to this modality. Medical Infrared Imaging: Principles and Practices covers new ideas concepts and technologies along with historical background and clinical applications. The book begins by exploring worldwide advances in the medical applications of thermal imaging systems. It covers technology and hardware including detectors detector materials un-cooled focal plane arrays high performance systems camera characterization electronics for on-chip image processing optics and cost-reduction designs. It then discusses the physiological basis of the thermal signature and its interpretation in a medical setting. The book also covers novel and emerging techniques the complexities and importance of protocols for effective and reproducible results storage and retrieval of thermal images and ethical obligations. Of interest to both the medical and biomedical engineering communities the book explores many opportunities for developing and conducting multidisciplinary research in many areas of medical infrared imaging. These range from clinical quantification to intelligent image processing for enhancement of the interpretation of images and for further development of user-friendly high-resolution thermal cameras. These would enable the wide use of infrared imaging as a viable noninvasive low-cost first-line detection modality. | Medical Infrared Imaging Principles and Practices

GBP 56.99
1

Electrostatic Discharge Protection Advances and Applications

Electrostatic Discharge Protection Advances and Applications

Electrostatic discharge (ESD) is one of the most prevalent threats to electronic components. In an ESD event a finite amount of charge is transferred from one object (i. e. human body) to another (i. e. microchip). This process can result in a very high current passing through the microchip within a very short period of time. Thus more than 35 percent of single-event chip damages can be attributed to ESD events and designing ESD structures to protect integrated circuits against the ESD stresses is a high priority in the semiconductor industry. Electrostatic Discharge Protection: Advances and Applications delivers timely coverage of component- and system-level ESD protection for semiconductor devices and integrated circuits. Bringing together contributions from internationally respected researchers and engineers with expertise in ESD design optimization modeling simulation and characterization this book bridges the gap between theory and practice to offer valuable insight into the state of the art of ESD protection. Amply illustrated with tables figures and case studies the text: Instills a deeper understanding of ESD events and ESD protection design principles Examines vital processes including Si CMOS Si BCD Si SOI and GaN technologies Addresses important aspects pertinent to the modeling and simulation of ESD protection solutions Electrostatic Discharge Protection: Advances and Applications provides a single source for cutting-edge information vital to the research and development of effective robust ESD protection solutions for semiconductor devices and integrated circuits. | Electrostatic Discharge Protection Advances and Applications

GBP 69.99
1

Indwelling Neural Implants Strategies for Contending with the In Vivo Environment

Indwelling Neural Implants Strategies for Contending with the In Vivo Environment

Despite enormous advances made in the development of external effector prosthetics over the last quarter century significant questions remain especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components including those that arise from the chemical mechanical thermal and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair. | Indwelling Neural Implants Strategies for Contending with the In Vivo Environment

GBP 59.99
1

MEMS Fundamental Technology and Applications

MEMS Fundamental Technology and Applications

The microelectromechanical systems (MEMS) industry has experienced explosive growth over the last decade. Applications range from accelerometers and gyroscopes used in automotive safety to high-precision on-chip integrated oscillators for reference generation and mobile phones. MEMS: Fundamental Technology and Applications brings together groundbreaking research in MEMS technology and explores an eclectic set of novel applications enabled by the technology. The book features contributions by top experts from industry and academia from around the world. The contributors explain the theoretical background and supply practical insights on applying the technology. From the historical evolution of nano micro systems to recent trends they delve into topics including: Thin-film integrated passives as an alternative to discrete passives The possibility of piezoelectric MEMS Solutions for MEMS gyroscopes Advanced interconnect technologies Ambient energy harvesting Bulk acoustic wave resonators Ultrasonic receiver arrays using MEMS sensors Optical MEMS-based spectrometers The integration of MEMS resonators with conventional circuitry A wearable inertial and magnetic MEMS sensor assembly to estimate rigid body movement patterns Wireless microactuators to enable implantable MEMS devices for drug delivery MEMS technologies for tactile sensing and actuation in robotics MEMS-based micro hot-plate devices Inertial measurement units with integrated wireless circuitry to enable convenient continuous monitoring Sensors using passive acousto-electric devices in wired and wireless systems Throughout the contributors identify challenges and pose questions that need to be resolved paving the way for new applications. Offering a wide view of the MEMS landscape this is an invaluable resource for anyone working to develop and commercialize MEMS applications. | MEMS Fundamental Technology and Applications

GBP 74.99
1