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Randomized Phase II Cancer Clinical Trials

Randomized Phase II Cancer Clinical Trials

In cancer research a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems oncologists and biostatisticians have begun to use a randomized phase II trial that compares an experimental therapy with a prospective control therapy. Randomized Phase II Cancer Clinical Trials explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase II trials stem from single-arm phase II trials and many phase II cancer clinical trials still use single-arm designs. The book then presents methods for randomized phase II trials and describes statistical methods for both single-arm and randomized phase II trials. Although the text focuses on phase II cancer clinical trials the statistical methods covered can also be used (with minor modifications) in phase II trials for other diseases and in phase III cancer clinical trials. Suitable for cancer clinicians and biostatisticians this book shows how randomized phase II trials with a prospective control resolve the shortcomings of traditional single-arm phase II trials. It provides readers with numerous statistical design and analysis methods for randomized phase II trials in oncology.

GBP 44.99
1

Multinary Alloys Based on II-VI Semiconductors

Multinary Alloys Based on II-VI Semiconductors

A companion volume to Ternary Alloys Based on II-VI Semiconductor Compounds (CRC Press 2013) and Quaternary Alloys Based on II-VI Semiconductor Compounds (CRC Press 2014) Multinary Alloys Based on II-VI Semiconductors provides up-to-date experimental and theoretical information on phase relations based on II-VI semiconductor systems with five or more components. Featuring detailed figures and extensive references this book:Delivers a critical evaluation of many industrially important systems presented in the form of two-dimensional sections for the condensed phasesSummarizes the data from the last 15–20 years of literature on the study of organometallic compounds which include zinc cadmium or mercury and sulfur selenium or telluriumClassifies all materials according to the periodic table groups of their constituent atoms that is possible combinations of Zn Cd and Hg with chalcogens S Se and Te and additional components in the order of their group numberSpecifies the diagram type possible phase transformations and physical–chemical interaction of the components methods of equilibrium investigation thermodynamic characteristics and methods for sample preparation in each multinary database descriptionMultinary Alloys Based on II-VI Semiconductors contains valuable material useful for obtaining nanoscale II-VI semiconductors and for preparing thin films of these semiconductor materials as well as for exploring the biological and medicinal applications of organometallic compounds and for identifying new compounds with necessary properties.

GBP 59.99
1

Quaternary Alloys Based on II - VI Semiconductors

Quaternary Alloys Based on II - VI Semiconductors

Doped by isovalent or heterovalent foreign impurities II–VI semiconductor compounds enable control of optical and electronic properties making them ideal in detectors solar cells and other precise device applications. Quaternary alloys allow a simultaneous adjustment of band gap and lattice constant increasing radiant efficiency at a wide range of wavelengths. Quaternary Alloys Based on II–VI Semiconductors consolidates data pertaining to diagrams of quaternary systems based on these semiconductor compounds. The book illustrates up-to-date experimental and theoretical information about phase relations based on II–VI semiconductor systems with four components. It critically evaluates many industrially significant systems presented in two-dimensional sections for the condensed phases. The author classifies all materials according to the periodic groups of their constituent atoms and additional components in the order of their group number. Each quaternary database description contains brief information on the diagram type possible phase transformations and physical–chemical interactions of the components thermodynamic characteristics and methods for equilibrium investigation and sample preparation. Most of the phase diagrams are in their original form. For those with varying published data the text includes several versions for comparison. This book provides invaluable data for technologists and researchers involved in developing and manufacturing II–VI semiconductors at industrial and national laboratories. It is also suitable for phase relations researchers inorganic chemists and semiconductor physicists as well as graduate students in materials science and engineering. Check out the companion books: Ternary Alloys Based on II–VI Semiconductor Compounds and | Quaternary Alloys Based on II - VI Semiconductors

GBP 59.99
1

Ethnomusicology: A Contemporary Reader Volume II

High-Speed Rail in Poland Advances and Perspectives

High-Speed Rail in Poland Advances and Perspectives

The Railway Research Institute (Instytut Kolejnictwa) in Warsaw was established in 1951 and was until 2000 part of the Polish State Railways (PKP). At present it serves as an independent entity it is subordinated to the minister responsible for transport. Since its inception the Institute has been the centre of competence for technology technique and organization of operation and services in rail transport particularly in respect to innovation. One of its fundamental tasks also includes activities connected with safety which are carried out in close cooperation with the National Safety Authority i. e. the Office of Rail Transport. At the same time the Institute participated in the process of upgrading and modernization of the rail network in Poland. Experience in high speed rail gained as a result of international cooperation and basing on the effort to increase speed on railway lines in Poland (so far 200 km/h) is included in the monograph “Koleje Dużych Prędkości w Polsce” (High Speed Rail in Poland) published in 2015 for the benefit of the Polish reader. This monograph aims at reaching an international audience of experts so as to present Polish determinants of HSR implementation. In order to elaborate this monograph apart from specialists from the Railway Research Institute experts from other research and academic centres were invited. Not only presenting a wide range of problems connected with future construction of High Speed Lines in Polish conditions but also a number of operational ones. The authors have created a reference work of universal character solving problems in order to build and operate high speed rail systems in countries on a similar level of development as Poland. Features:providing requirements for design and upgrade of engineering works on High Speed Rail developmentinformation on restructuring and building railway lines for countries starting to develop a High Speed Rail systemdealing with organizational engineering socioeconomic and economic demands for transport services and the formation of human resources for constructing and operting a High Speed Rails system. Presenting these problems on the international arena will facilitate future cooperation and application of world experience to create HSR in Poland and integrate the Polish HSR network into the international one. | High-Speed Rail in Poland Advances and Perspectives

GBP 44.99
1

Bionanotechnology II Global Prospects

Building in Security at Agile Speed

Building in Security at Agile Speed

Today's high-speed and rapidly changing development environments demand equally high-speed security practices. Still achieving security remains a human endeavor a core part of designing generating and verifying software. Dr. James Ransome and Brook S. E. Schoenfield have built upon their previous works to explain that security starts with people; ultimately humans generate software security. People collectively act through a particular and distinct set of methodologies processes and technologies that the authors have brought together into a newly designed holistic generic software development lifecycle facilitating software security at Agile DevOps speed. —Eric. S. Yuan Founder and CEO Zoom Video Communications Inc. It is essential that we embrace a mantra that ensures security is baked in throughout any development process. Ransome and Schoenfield leverage their abundance of experience and knowledge to clearly define why and how we need to build this new model around an understanding that the human element is the ultimate key to success. —Jennifer Sunshine Steffens CEO of IOActive Both practical and strategic Building in Security at Agile Speed is an invaluable resource for change leaders committed to building secure software solutions in a world characterized by increasing threats and uncertainty. Ransome and Schoenfield brilliantly demonstrate why creating robust software is a result of not only technical but deeply human elements of agile ways of working. —Jorgen Hesselberg author of Unlocking Agility and Cofounder of Comparative Agility The proliferation of open source components and distributed software services makes the principles detailed in Building in Security at Agile Speed more relevant than ever. Incorporating the principles and detailed guidance in this book into your SDLC is a must for all software developers and IT organizations. —George K Tsantes CEO of Cyberphos former partner at Accenture and Principal at EYDetailing the people processes and technical aspects of software security Building in Security at Agile Speed emphasizes that the people element remains critical because software is developed managed and exploited by humans. This book presents a step-by-step process for software security that uses today’s technology operational business and development methods with a focus on best practice proven activities processes tools and metrics for any size or type of organization and development practice.

GBP 44.99
1

Hydrometallurgy in Extraction Processes Volume II

Environmental Statistics with S-PLUS

Multilevel and Longitudinal Modeling Using Stata Volume II Categorical Responses Counts and Survival

Doing News Framing Analysis II Empirical and Theoretical Perspectives

CMOS Analog Integrated Circuits High-Speed and Power-Efficient Design Second Edition

High-Speed Precision Motion Control

High-Speed Precision Motion Control

Edited by Takashi Yamaguchi Mitsuo Hirate and Chee Khiang Pang with contributions from pioneers known for their ground-breaking work High-Speed Precision Motion Control discusses high-precision and fast servo controls in hard disk drives (HDDs). The chapter authors describe the control technologies they’ve developed most of which have already been successfully applied to mass production of HDDs. As the proposed methodologies have been verified on commercial HDDs at the very least these advanced control technologies can also be readily applied to precision motion control of other mechatronic systems e. g. scanners micro-positioners photocopiers atomic force microscopes (AFMs) etc. Each self-contained chapter progresses from concept to technique and presents application examples in automotive aerospace aeronautical and manufacturing engineering. The control technologies are categorized into high-speed servo control precision control and environment-friendly control making it easy to find an appropriate control technology according to their domain of application. The book also makes MATLAB®/SIMULINK® codes for benchmark problems available for download. The control technologies described range from fundamental classical control theories to advanced topics such as multi-rate control. The content contains a healthy balance between materials from the contributor’s research works and that in the wider literature. The resulting resource empowers engineers and managers with the knowledge and know-how to make important decisions and policies.

GBP 74.99
1

The Official History of Privatisation Vol. II Popular Capitalism 1987-97

The Official History of Privatisation Vol. II Popular Capitalism 1987-97

This is Volume II of Professor Parker's authoritative Official History of Privatisation covering the period from the re-election of Margaret Thatcher in 1987 to the election of Tony Blair in 1997. Volume II considers in detail several of the major privatisations including those of airports steel water electricity coal and the railways as well as a number of smaller ones. Each privatisation involved major challenges in terms of industrial restructuring organising successful sales and in a number of cases establishing effective regulatory regimes. The policy evolved and new methods of selling and regulating were put in place that enabled further disposals to occur. Monolithic nationalised industries with their emphasis on the benefits of economies of scale vertical integration and rationalisation were replaced by industrial structures rooted in the importance of commercial management risk taking and competition. In government departments and parts of the National Health Service direct employees were replaced by private contractors and private investment became a characteristic of public infrastructure in the form of PFI/PPP schemes. This study draws heavily on the official records of the British government to which the author was given full access and on interviews with the leading figures involved in each of the privatisations including ex-ministers civil servants business and City figures as well as academics that have studied the subject. This book will of great interest to students of privatisation British political history and of business and economics in general. | The Official History of Privatisation Vol. II Popular Capitalism 1987-97

GBP 46.99
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Conventional Flowmeters Volume II

Conventional Flowmeters Volume II

Conventional Flowmeters covers origin principle of operation development advantages and disadvantages applications and frontiers of research for conventional technology flowmeters which include differential pressure and primary elements positive displacement turbine open channel and variable area. There are more conventional technology meters being used in the field than new-technology meters. New developments such as more accurate pressure transmitters new primary elements such as cone elements reversible flow and dual rotor turbine meters and variable area meters with transmitters and a signal output are discussed. Features: Offers a working knowledge of the origin and development of the more traditional technology flowmeters: differential pressure and primary elements positive displacement turbine open channel and variable area Describes how these conventional meters still fit into what is being called Industry 4. 0 Discusses the advantages and disadvantages of conventional technology meters and provides a rationale for retaining or replacing these meters Focuses on the origin development operating principles and applications for the meters Explores the development of each conventional flowmeter type including the roles of companies such as Siemens ABB Emerson Foxboro KROHNE and Endress+Hauser This book is designed for anyone involved with flowmeters and instrumentation including product and marketing managers strategic planners application engineers and distributors. | Conventional Flowmeters Volume II

GBP 84.99
1

Engineering Production-Grade Shiny Apps

Engineering Production-Grade Shiny Apps

From the Reviews [This book] contains an excellent blend of both Shiny-specific topics … and practical advice from software development that fits in nicely with Shiny apps. You will find many nuggets of wisdom sprinkled throughout these chapters…. Eric Nantz Host of the R-Podcast and the Shiny Developer Series (from the Foreword) [This] book is a gradual and pleasant invitation to the production-ready shiny apps world. It …exposes a comprehensive and robust workflow powered by the {golem} package. [It] fills the not yet covered gap between shiny app development and deployment in such a thrilling way that it may be read in one sitting…. In the industry world where processes robustness is a key toward productivity this book will indubitably have a tremendous impact. David Granjon Sr. Expert Data Science Novartis Presented in full color Engineering Production-Grade Shiny Apps helps people build production-grade shiny applications by providing advice tools and a methodology to work on web applications with R. This book starts with an overview of the challenges which arise from any big web application project: organizing work thinking about the user interface the challenges of teamwork and the production environment. Then it moves to a step-by-step methodology that goes from the idea to the end application. Each part of this process will cover in detail a series of tools and methods to use while building production-ready shiny applications. Finally the book will end with a series of approaches and advice about optimizations for production. Features Focused on practical matters: This book does not cover Shiny concepts but practical tools and methodologies to use for production. Based on experience: This book is a formalization of several years of experience building Shiny applications. Original content: This book presents new methodologies and tooling not just a review of what already exists. Engineering Production-Grade Shiny Apps covers medium to advanced content about Shiny so it will help people that are already familiar with building apps with Shiny and who want to go one step further.

GBP 48.99
1

Stochastic Process Optimization using Aspen Plus

Stochastic Process Optimization using Aspen Plus

Stochastic Process Optimization using Aspen® PlusBookshop Category: Chemical EngineeringOptimization can be simply defined as choosing the best alternative among a set of feasible options. In all the engineering areas optimization has a wide range of applications due to the high number of decisions involved in an engineering environment. Chemical engineering and particularly process engineering is not an exception; thus stochastic methods are a good option to solve optimization problems for the complex process engineering models. In this book the combined use of the modular simulator Aspen® Plus and stochastic optimization methods codified in MATLAB is presented. Some basic concepts of optimization are first presented then strategies to use the simulator linked with the optimization algorithm are shown. Finally examples of application for process engineering are discussed. The reader will learn how to link the process simulator Aspen® Plus and stochastic optimization algorithms to solve process design problems. They will gain ability to perform multi-objective optimization in several case studies. Key Features:• The book links simulation and optimization through numerical analyses and stochastic optimization techniques • Includes use of examples to illustrate the application of the concepts and specific guidance on the use of software (Aspen® Plus Excel MATLB) to set up and solve models representing complex problems. • Illustrates several examples of applications for the linking of simulation and optimization software with other packages for optimization purposes. • Provides specific information on how to implement stochastic optimization with process simulators. • Enable readers to identify practical and economic solutions to problems of industrial relevance enhancing the safety operation environmental and economic performance of chemical processes. | Stochastic Process Optimization using Aspen Plus®

GBP 44.99
1

Compact Heat Exchangers for Energy Transfer Intensification Low Grade Heat and Fouling Mitigation

Compact Heat Exchangers for Energy Transfer Intensification Low Grade Heat and Fouling Mitigation

Compact Heat Exchangers for Energy Transfer Intensification: Low-Grade Heat and Fouling Mitigation provides theoretical and experimental background on heat transfer intensification in modern heat exchangers. Emphasizing applications in complex heat recovery systems for the process industries this book: Covers various issues related to low-grade heat including waste heat from industry and buildings storage and transport of thermal energy and heat transfer equipment requirements Explains the basic principles terminology and heat transfer aspects of compactness as well as the concept of intensified heat area targets at process integration Pays special attention to the mitigation of fouling in heat exchangers and their systems describing fouling deposition and threshold fouling mechanisms Delivers a thoughtful analysis of the economics of implementation considering energy–capital trade-off capital cost estimation and energy prices Presents illustrative case studies of specific applications in food and chemical production plants Compact Heat Exchangers for Energy Transfer Intensification: Low-Grade Heat and Fouling Mitigation not only highlights key developments in compact heat exchangers but also instills a practical knowledge of the latest process integration and heat transfer enhancement methodologies. | Compact Heat Exchangers for Energy Transfer Intensification Low Grade Heat and Fouling Mitigation

GBP 84.99
1

Autodesk Inventor 2024 Essentials Plus

Autodesk Inventor 2024 Essentials Plus

Autodesk Inventor 2024 Essentials Plus provides the foundation for a hands-on course that covers basic and advanced Autodesk Inventor features used to create edit document and print parts and assemblies. You learn about part and assembly modeling through real-world exercises. Autodesk Inventor 2024 Essentials Plus demonstrates critical CAD concepts from basic sketching and modeling through advanced modeling techniques as it equips you with the skills to master this powerful professional tool. The book walks you through every component of the software including the user interface toolbars dialogue boxes sketch tools drawing views assembly modeling and more. Its unique modular organization puts key information at your fingertips while step-by-step tutorials make it an ideal resource for self-learning. Packed with vivid illustrations and practical exercises that emphasize modern-day applications Autodesk Inventor 2024 Essentials Plus will prepare you for work in the real world. Each chapter is organized into four sections: objectives which describe the content and learning objectives; topic coverage which presents a concise review of the topic; exercises which present the workflow for a specific command or process through illustrated step-by-step instructions; and finally a checking your skills section which tests your understanding of the material. Who Should Use this Manual? This manual is designed to be used in instructor-led courses although you may also find it helpful as a self-paced learning tool. It is recommended that you have a working knowledge of Microsoft® Windows® as well as a working knowledge of mechanical design principles.

GBP 66.99
1

Autodesk Inventor 2023 Essentials Plus

Autodesk Inventor 2023 Essentials Plus

Autodesk Inventor 2023 Essentials Plus provides the foundation for a hands-on course that covers basic and advanced Autodesk Inventor features used to create edit document and print parts and assemblies. You learn about part and assembly modeling through real-world exercises. Autodesk Inventor 2023 Essentials Plus demonstrates critical CAD concepts from basic sketching and modeling through advanced modeling techniques as it equips you with the skills to master this powerful professional tool. The book walks you through every component of the software including the user interface toolbars dialogue boxes sketch tools drawing views assembly modeling and more. Its unique modular organization puts key information at your fingertips while step-by-step tutorials make it an ideal resource for self-learning. Packed with vivid illustrations and practical exercises that emphasize modern-day applications Autodesk Inventor 2023 Essentials Plus will prepare you for work in the real world. Each chapter is organized into four sections. Objectives which describe the content and learning objectives; topic coverage which presents a concise review of the topic; exercises which present the workflow for a specific command or process through illustrated step-by-step instructions; and finally a checking your skills section which tests your understanding of the material. Who Should Use this Manual? This manual is designed to be used in instructor-led courses although you may also find it helpful as a self-paced learning tool. It is recommended that you have a working knowledge of Microsoft® Windows® as well as a working knowledge of mechanical design principles.

GBP 65.00
1

CMOS Analog Integrated Circuits High-Speed and Power-Efficient Design

CMOS Analog Integrated Circuits High-Speed and Power-Efficient Design

High-speed power-efficient analog integrated circuits can be used as standalone devices or to interface modern digital signal processors and micro-controllers in various applications including multimedia communication instrumentation and control systems. New architectures and low device geometry of complementary metaloxidesemiconductor (CMOS) technologies have accelerated the movement toward system on a chip design which merges analog circuits with digital and radio-frequency components. CMOS: Analog Integrated Circuits: High-Speed and Power-Efficient Design describes the important trends in designing these analog circuits and provides a complete in-depth examination of design techniques and circuit architectures emphasizing practical aspects of integrated circuit implementation. Focusing on designing and verifying analog integrated circuits the author reviews design techniques for more complex components such as amplifiers comparators and multipliers. The book details all aspects from specification to the final chip of the development and implementation process of filters analog-to-digital converters (ADCs) digital-to-analog converters (DACs) phase-locked loops (PLLs) and delay-locked loops (DLLs). It also describes different equivalent transistor models design and fabrication considerations for high-density integrated circuits in deep-submicrometer process circuit structures for the design of current mirrors and voltage references topologies of suitable amplifiers continuous-time and switched-capacitor circuits modulator architectures and approaches to improve linearity of Nyquist converters. The text addresses the architectures and performance limitation issues affecting circuit operation and provides conceptual and practical solutions to problems that can arise in the design process. This reference provides balanced coverage of theoretical and practical issues that will allow the reader to design CMOS analog integrated circuits with improved electrical performance. The chapters contain easy-to-follow mathematical derivations of all equations and formulas graphical plots and open-ended design problems to help determine most suitable architecture for a given set of performance specifications. This comprehensive and illustrative text for the design and analysis of CMOS analog integrated circuits serves as a valuable resource for analog circuit designers and graduate students in electrical engineering. | CMOS Analog Integrated Circuits High-Speed and Power-Efficient Design

GBP 77.99
1

A Treatise of the Laws for the Relief and Settlement of the Poor Volume II

Modeling and Design of Electromagnetic Compatibility for High-Speed Printed Circuit Boards and Packaging