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Randomized Phase II Cancer Clinical Trials

Randomized Phase II Cancer Clinical Trials

In cancer research a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems oncologists and biostatisticians have begun to use a randomized phase II trial that compares an experimental therapy with a prospective control therapy. Randomized Phase II Cancer Clinical Trials explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase II trials stem from single-arm phase II trials and many phase II cancer clinical trials still use single-arm designs. The book then presents methods for randomized phase II trials and describes statistical methods for both single-arm and randomized phase II trials. Although the text focuses on phase II cancer clinical trials the statistical methods covered can also be used (with minor modifications) in phase II trials for other diseases and in phase III cancer clinical trials. Suitable for cancer clinicians and biostatisticians this book shows how randomized phase II trials with a prospective control resolve the shortcomings of traditional single-arm phase II trials. It provides readers with numerous statistical design and analysis methods for randomized phase II trials in oncology.

GBP 44.99
1

Multinary Alloys Based on II-VI Semiconductors

Multinary Alloys Based on II-VI Semiconductors

A companion volume to Ternary Alloys Based on II-VI Semiconductor Compounds (CRC Press 2013) and Quaternary Alloys Based on II-VI Semiconductor Compounds (CRC Press 2014) Multinary Alloys Based on II-VI Semiconductors provides up-to-date experimental and theoretical information on phase relations based on II-VI semiconductor systems with five or more components. Featuring detailed figures and extensive references this book:Delivers a critical evaluation of many industrially important systems presented in the form of two-dimensional sections for the condensed phasesSummarizes the data from the last 15–20 years of literature on the study of organometallic compounds which include zinc cadmium or mercury and sulfur selenium or telluriumClassifies all materials according to the periodic table groups of their constituent atoms that is possible combinations of Zn Cd and Hg with chalcogens S Se and Te and additional components in the order of their group numberSpecifies the diagram type possible phase transformations and physical–chemical interaction of the components methods of equilibrium investigation thermodynamic characteristics and methods for sample preparation in each multinary database descriptionMultinary Alloys Based on II-VI Semiconductors contains valuable material useful for obtaining nanoscale II-VI semiconductors and for preparing thin films of these semiconductor materials as well as for exploring the biological and medicinal applications of organometallic compounds and for identifying new compounds with necessary properties.

GBP 59.99
1

World War II A Global History

World War II A Global History

Fully revised and restructured the sixth edition of World War II: A Global History offers students a concise and yet thorough textbook that examines history’s bloodiest conflict. The chapters alternate between chronological chapters on Europe and Asia-Pacific and thematic chapters on innovations home fronts brutal regimes and logistics. This textbook includes the following features: A lively narrative of facts events people and ideas that incorporates thoughtful analysis New material and restructured content on global factors that affected the causes conduct and consequences of World War II Balanced pace that does not bog readers down in too many details yet gives them sufficient depth and breadth for context Chapters sections and sidebars arranged in ways that can complement lectures and assignments Fifty new photographs that illustrate the human condition and weaponry during World War II. Global in focus by blending both geographic and thematic chapters to ensure readers gain a comprehensive understanding of impact of the war worldwide this is the perfect volume for all students of the biggest global conflict of the twentieth century. | World War II A Global History

GBP 115.00
1

Quaternary Alloys Based on II - VI Semiconductors

Quaternary Alloys Based on II - VI Semiconductors

Doped by isovalent or heterovalent foreign impurities II–VI semiconductor compounds enable control of optical and electronic properties making them ideal in detectors solar cells and other precise device applications. Quaternary alloys allow a simultaneous adjustment of band gap and lattice constant increasing radiant efficiency at a wide range of wavelengths. Quaternary Alloys Based on II–VI Semiconductors consolidates data pertaining to diagrams of quaternary systems based on these semiconductor compounds. The book illustrates up-to-date experimental and theoretical information about phase relations based on II–VI semiconductor systems with four components. It critically evaluates many industrially significant systems presented in two-dimensional sections for the condensed phases. The author classifies all materials according to the periodic groups of their constituent atoms and additional components in the order of their group number. Each quaternary database description contains brief information on the diagram type possible phase transformations and physical–chemical interactions of the components thermodynamic characteristics and methods for equilibrium investigation and sample preparation. Most of the phase diagrams are in their original form. For those with varying published data the text includes several versions for comparison. This book provides invaluable data for technologists and researchers involved in developing and manufacturing II–VI semiconductors at industrial and national laboratories. It is also suitable for phase relations researchers inorganic chemists and semiconductor physicists as well as graduate students in materials science and engineering. Check out the companion books: Ternary Alloys Based on II–VI Semiconductor Compounds and | Quaternary Alloys Based on II - VI Semiconductors

GBP 59.99
1

Safety-II in Practice Developing the Resilience Potentials

Safety-II in Practice Developing the Resilience Potentials

Safety-I is defined as the freedom from unacceptable harm. The purpose of traditional safety management is therefore to find ways to ensure this ‘freedom’. But as socio-technical systems steadily have become larger and less tractable this has become harder to do. Resilience engineering pointed out from the very beginning that resilient performance - an organisation’s ability to function as required under expected and unexpected conditions alike – required more than the prevention of incidents and accidents. This developed into a new interpretation of safety (Safety-II) and consequently a new form of safety management. Safety-II changes safety management from protective safety and a focus on how things can go wrong to productive safety and a focus on how things can and do go well. For Safety-II the aim is not just the elimination of hazards and the prevention of failures and malfunctions but also how best to develop an organisation’s potentials for resilient performance – the way it responds monitors learns and anticipates. That requires models and methods that go beyond the Safety-I toolbox. This book introduces a comprehensive approach for the management of Safety-II called the Resilience Assessment Grid (RAG). It explains the principles of the RAG and how it can be used to develop the resilience potentials. The RAG provides four sets of diagnostic and formative questions that can be tailored to any organisation. The questions are based on the principles of resilience engineering and backed by practical experience from several domains. Safety-II in Practice is for both the safety professional and academic reader. For the professional it presents a workable method (RAG) for the management of Safety-II with a proven track record. For academic and student readers the book is a concise and practical presentation of resilience engineering. | Safety-II in Practice Developing the Resilience Potentials

GBP 31.99
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Vatican II and New Thinking about Catholic Education The impact and legacy of Gravissimum Educationis

Vatican II and New Thinking about Catholic Education The impact and legacy of Gravissimum Educationis

It is only in the years since Vatican II that the new thinking about Catholic education has crystalised into shape. Vatican II and New Thinking about Catholic Education provides an opportune moment to take stock of the impact of Vatican II on Catholic education. This volume considers the various ways in which Vatican II and its teaching on education has been received and engages with the challenges and testing times that beset faith-based education in the twenty-first century. With insights from an international range of leading and influential advocates of Catholic education the volume demonstrates the differing contexts of Catholic education and explores the ways in which Vatican II’s teaching on education has been received over the past four or five decades. | Vatican II and New Thinking about Catholic Education The impact and legacy of Gravissimum Educationis

GBP 42.99
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Ethnomusicology: A Contemporary Reader Volume II

Ethnomusicology: A Contemporary Reader Volume II

Ethnomusicology: A Contemporary Reader Volume II provides an overview of developments in the study of ethnomusicology in the twenty-first century offering an introduction to contemporary issues relevant to the field. Nineteen essays written by an international array of scholars highlight the relationship between current issues in the discipline and ethnomusicologists’ engagement with issues such as advocacy poverty and social participation maintaining intangible cultural heritages and ecological concerns. It provides a forum for rethinking the discipline’s identity in terms of major themes and issues to which ethnomusicologists have turned their attention since Volume I published in 2005. The collection of essays is organized into six sections: Property and Rights Applied Practice Knowledge and Agency Community and Social Space Embodiment and Cognition Curating Sound Volume II serves as a basic introduction to the best writing in the field for students professors and music professionals perfect for both introductory and upper level courses in world music. Together with the first volume Ethnomusicology: A Contemporary Reader Volume II provides a comprehensive survey of current research directions.

GBP 56.99
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Smith: Psychology of Education II (4-vol. set)

Smith: Psychology of Education II (4-vol. set)

This new title in Routledge’s Major Themes in Education series is a four-volume collection of major works of scholarship. It is an essential successor to an earlier Routledge anthology Psychology of Education (978-0-415-19302-3) (2000) edited by Peter K. Smith and Anthony D. Pellegrini. Research in and around psychology and education has experienced dramatic growth in recent years. Psychology of Education (2000) was the first comprehensive collection of the field’s canonical and cutting-edge research and this new collection takes full account of the many important developments that have taken place since its appearance. Psychology of Education II also includes coverage of areas without the scope of the first collection. With a full index together with a comprehensive introduction newly written by the editor which places the collected material in its historical and intellectual context Psychology of Education II is an indispensable work of reference. | Smith: Psychology of Education II (4-vol. set)

GBP 625.00
1

Biolinguistics vol II

Biolinguistics vol II

Biolinguistics the study of the relation between humans’ biology and the properties of the Language Faculty is an emergent and lively field and is central to linguistics. It gives rise to lively debates on the origin of language and the specificity of human language in the animal kingdom as well as the biological basis of the human language capacities. This new four volume collection assembles the most important contributions to the field exploring the foundations of the subject and language development variation in languages and biology and complexities in language and biology. | Biolinguistics vol II

GBP 250.00
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Women's University Narratives 1890-1945 Part II Volume II

Women's University Narratives 1890-1945 Part II Volume II

The years 1890-1945 saw an unprecedented outpouring of fiction focused on British university life much of it reflecting the drastic change that had swept through the higher education system in the late nineteenth century. Among these narratives a significant subgroup focused on the lives of women students newly admitted to the structures of higher education system their presence still stridently and sometimes even violently opposed especially at Oxbridge. These novels and short stories collected here largely unknown today were widely discussed and debated in the public sphere during the early twentieth century contributing not only to the formation of public knowledge and opinion about education through cultural figures like the ‘Girton Girl’ or the ‘undergraduette ’ but also sparking debate about many wider social and cultural issues from the place of the women writer in the literary scene to the emergence of new discourses around psychology and the body. The majority have not been reprinted since their original publication and until now have been rarely available to scholars. The publication of Women’s University Narratives 1890-1945 therefore provides a major new resource for scholarship in many areas including women’s studies educational history and literary and cultural modernism. | Women's University Narratives 1890-1945 Part II Volume II

GBP 130.00
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Bionanotechnology II Global Prospects

Bionanotechnology II Global Prospects

The impact and importance of nanotechnology continues to grow and nanomedicine and biotechnology have become areas of increased development. Biomedical engineers who work with biological processes and structures must have a deeply rooted understanding of the role of bionanotechnology a rapidly evolving sector of the nanotechnology field. Bionanotechnology II: Global Prospects a follow-up to the editor’s highly successful first volume contains 26 entirely new contributions that provide a broad survey of research shaping this critical field. With coverage of technical and nontechnical areas the book offers representative reporting on a wide variety of activity from around the world. It discusses the role of nanotechnology in novel medical devices bioanalytical technologies and nanobiomaterials. Topics discussed include: Emerging microscale technologies Bionanotech-based water treatment Tissue engineering and drug delivery Antimicrobial nanomaterials in the textile industry Bionanotechnology applications in plants and agriculture With contributions from researchers in Israel Egypt Iran Jordan Singapore South Africa Turkey Thailand Argentina the United Kingdom and the United States this volume presents a worldwide perspective on some of the critical areas shaping bionanotechnology today. | Bionanotechnology II Global Prospects

GBP 51.99
1

Bayesian Designs for Phase I-II Clinical Trials

Bayesian Designs for Phase I-II Clinical Trials

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time if promising preclinical results do not translate into a real treatment advance it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center this book shows how Bayesian designs for early-phase clinical trials can explore refine and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity. | Bayesian Designs for Phase I-II Clinical Trials

GBP 38.99
1

Localization Of Putative Steroid Receptors Volume II: Clinically Oriented Studies

Localization Of Putative Steroid Receptors Volume II: Clinically Oriented Studies

These volumes represent the state-of-the-art in morphological methods for detection of steroid receptors. Some physician authors have applied many of the new methodologies in clinical research projects deisgned to improve medical practice and these attempts have been placed in Volume II. The Background and recent advances presented here are intended to stimulate further experimentation and new innovations and spur clinical trials by all investigators with an interest in steroid hormones cell biology and clinical oncology. | Localization Of Putative Steroid Receptors Volume II: Clinically Oriented Studies

GBP 140.00
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Fat Absorption Volume II

Fat Absorption Volume II

This book provides an authoritative and comprehensive source of information on the biochemical an metabolic aspects of digestion and absorption of different dietary fats and other lipids with minimal discussion of the physical chemistry of the process which has been covered in great detail in previous reviews. It is intended for both researchers and practitioners in the biomedical field who require detailed knowledge of the biomedical and metabolic transformations involed in the intestinal digestion and resynthesis of dietary fats and other lipids. | Fat Absorption Volume II

GBP 120.00
1

Spectroscopy in Biochemistry Volume II

Spectroscopy in Biochemistry Volume II

This book has been written in part with the aim of providing a text which will be useful in teaching the biochemical applications of spectroscopy. This book will be of particular use to the biochemist or biologist who does not have a background in spectroscopy but desires to find out what sort of information spectroscopy can provide. Attention was limited to those techniques most frequently used and which at present have the widest applications. | Spectroscopy in Biochemistry Volume II

GBP 205.00
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Architecture in Detail II

Architecture in Detail II

Following on from Graham Bizley's successful Architecture in Detail Architecture in Detail II presents forty case studies of detailing on recent construction projects. Over 150 full colour drawings and photos provide a reference compendium for the professional architect seeking detailing inspiration. Originally featured in Building Design's in Detail magazine the included projects represent some of the most interesting and innovative techniques in recent architecture. Graham Bizley's beautifully presented detail drawings allow the architect to easily see how ideas and techniques can be applied to other projects. The book is organized by building type for quick and easy reference.

GBP 170.00
1